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Isolation of Pure Compound R/J/3 from Pluchea Indica (L.) Less. and its Anti-Amoebic Activities Against Entamoeba HGistolytica

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Title Isolation of Pure Compound R/J/3 from Pluchea Indica (L.) Less. and its Anti-Amoebic Activities Against Entamoeba HGistolytica
 
Creator Biswas, Ria
Dutta, P K
Achari, Basudeb
Bandyopadhyay, Durba
Mishra, Moumita
Pramanik, K C
Chatterjee, T K
 
Subject Chemistry
 
Description The plant Pluchea indica is known for its anti-inflammatory, anti-ulcer, anti-pyretic, hypoglycemic, diuretic and antimicrobial
activities besides many other pharmacological activities. We have isolated and purified seven compounds
from the methanolic root extract of this plant by column chromatography. The compounds were identified by
spectroscopic analyses. The anti-amoebic activities of the pure compound R/J/3 was investigated against the HM1
strain of Entamoeba histolytica. The compound, R/J/3 showed the most pronounced anti-proliferative activity at a
dose of 50 mg/ml. It also showed a marked activity on cell lysis of trophozoites, 4 h after administration. The cell lytic
activity was compared with metronidazole (5 mg/ml) as positive control.
 
Date 2007
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1147/1/PHYTOMEDICINE__14_(7%2D8)__534%2D537;2007[57].pdf
Biswas, Ria and Dutta, P K and Achari, Basudeb and Bandyopadhyay, Durba and Mishra, Moumita and Pramanik, K C and Chatterjee, T K (2007) Isolation of Pure Compound R/J/3 from Pluchea Indica (L.) Less. and its Anti-Amoebic Activities Against Entamoeba HGistolytica. Phytomedicine, 14 (7-8). pp. 534-537.
 
Relation http://dxdoi.org/10.1016/j.phymed.2006.11.003
http://www.eprints.iicb.res.in/1147/