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Differential Deletions of Chromosome 3p are Associated with the Development of Uterine Cervical Carcinoma in Indian Patients

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Title Differential Deletions of Chromosome 3p are Associated
with the Development of Uterine Cervical Carcinoma in
Indian Patients
 
Creator Dasgupta, S
Chakraborty, S B
Roy, A
Roychoudhury, Susanta
Panda, C K
 
Subject Molecular & Human Genetics
 
Description Background: Deletions in chromosome 3 occur frequently in uterine cervical carcinoma (CA-CX). The
common consensus regions deleted during CA-CX development are not well defined, and have not
been correlated with tumour progression.
Aims: To define specific regions of chromosome 3 deleted during development of CA-CX and to correlate
these with clinicopathological data.
Methods: Deletion mapping of chromosome 3 was done in seven cervical intraepithelial neoplasia
(CIN) and 43 primary CA-CX samples using 20 highly polymorphic microsatellite markers.
Results: Deletions of chromosome 3 were significantly associated with tumour progression. High frequencies
(33–53%) of loss of heterozygosity (LOH) were found in 3p26.1, 3p22.3, 3p21.2, and
3p13, suggesting the location of putative tumour suppressor genes (TSGs) in these regions. Among
these four regions, deletions in 3p21.2 were suggested to occur early during CA-CX development. A
significant correlation was found between LOH at 3p26.1 and 3p22.3 with tumour progression from
stage I/IIB to stage III/IV. No association was found with the highly deleted regions and human papillomavirus
positivity, parity, or menopausal status. Microsatellite size alteration was seen in only seven
of the samples. However, rare biallelic alterations were seen in and around the highly deleted regions.
Loss of normal copy of chromosome 3 and interstitial alterations in chromosome 3p were seen in some
samples.
Conclusion: These four regions on chromosome 3p may be differentially deleted during specific
stages of CA-CX development. The putative TSGs located in these regions may have a cumulative effect
on tumour progression.
 
Date 2003
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1165/1/26_JCPMP_Free_2003.pdf
Dasgupta, S and Chakraborty, S B and Roy, A and Roychoudhury, Susanta and Panda, C K (2003) Differential Deletions of Chromosome 3p are Associated with the Development of Uterine Cervical Carcinoma in Indian Patients. Journal of Clinical Pathology : Molecular Pathology, 56. pp. 263-269.
 
Relation http://dx.doi.org
http://www.eprints.iicb.res.in/1165/