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Infectivity and Attenuation of Leishmania Donovani Promastigotes II: Association of The Loss of Parasite Infectivity With the Terminal Galactosylation of Precursor Acceptors Present in Virulent Parasites by the Developmentally Regulated Galactosyltransferase

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Title Infectivity and Attenuation of Leishmania Donovani
Promastigotes II: Association of The Loss of Parasite Infectivity With the Terminal Galactosylation of Precursor Acceptors Present in Virulent Parasites by
the Developmentally Regulated Galactosyltransferase
 
Creator Bhaumik, S
Basu, R
De, Tripti
 
Subject Infectious Diseases and Immunology
 
Description The
β
1-4 galactosyltransferase enzyme of the
Leishmania
donovani
promastigotes, was found to be developmentally
regulated and expressed only in the attenuated parasites. The
enzymatic product of soluble determinants of virulent promastigotes
and the galactosyltransferase enzyme was found to
stimulate the macrophage burst activity but inhibit
in vitro
intracellular parasitism. In contrast, removal of terminal
galactose moieties from soluble determinants of attenuated
parasites resulted in the inhibition of macrophage respiratory
burst activity but did not now inhibit intracellular parasitism.
We propose that the terminal galactosylation of acceptor substrates
present in virulent parasites by the developmentally
regulated galactosyltransferase is associated with loss of parasite
virulence.
 
Date 2003
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1181/1/26_JCPMP_Free_2003.pdf
Bhaumik, S and Basu, R and De, Tripti (2003) Infectivity and Attenuation of Leishmania Donovani Promastigotes II: Association of The Loss of Parasite Infectivity With the Terminal Galactosylation of Precursor Acceptors Present in Virulent Parasites by the Developmentally Regulated Galactosyltransferase. Parasite Immunology, 25 (10). pp. 517-520.
 
Relation http://dx.doi.org/10.1111/j.1365-3024.2003.00660.x
http://www.eprints.iicb.res.in/1181/