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Allelic Imbalance at Chromosome 11 in Head and Neck Squamous Cell Carcinoma in an Indian Patient Population

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Title Allelic Imbalance at Chromosome 11 in Head and Neck
Squamous Cell Carcinoma in an Indian Patient Population
 
Creator Mondal, G
Tripathi, A
Bhattacharya, N
Sikdar, N
Roy, A
Sengupta, A
Roy, B
Panda, C K
Roychoudhury, Susanta
 
Subject Molecular & Human Genetics
 
Description Head and neck squamous cell carcinoma (HNSCC) is the
sixth most common human cancer in all parts of the
world, and it has been estimated that there are around
400 000 new cases each year worldwide.1 It accounts for about
30–40% of all cancer types in India and in the subcontinent.2
Epidemiological studies have linked chronic exposure to
tobacco, betel nut leaf quid, alcohol, and some environmental
factors to the occurrence of HNSCC,3 and the characteristic
molecular genetic events associated with the initiation and
progression of HNSCC are beginning to be understood. The
karyotypes of HNSCC tumours are complex, often near
triploid, and there are multiple numerical and structural
abnormalities, including deletions, balanced and unbalanced
translocations, isochromosomes, dicentric chromosomes, and
homogeneously staining regions.4 Classic cytogenetic analysis
of HNSCC tumours has identified a gradual increase in chromosomal
aberrations from premalignant to malignant
lesions.5 In other studies, consistent chromosomal deletions
and amplifications in several chromosome arms have been
reported.6 In addition, centromeric breakage in several
chromosomes has been shown to be important for the development
of HNSCC.7
 
Date 2003
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1191/1/45_JCPMP_Free_2003.pdf
Mondal, G and Tripathi, A and Bhattacharya, N and Sikdar, N and Roy, A and Sengupta, A and Roy, B and Panda, C K and Roychoudhury, Susanta (2003) Allelic Imbalance at Chromosome 11 in Head and Neck Squamous Cell Carcinoma in an Indian Patient Population. Journal Of Clinical Pathology, 56 (7). pp. 512-518.
 
Relation http://dx.doi.org/10.1136/jcp.56.7.512
http://www.eprints.iicb.res.in/1191/