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Ethnic India: A Genomic View, With Special Reference to Peopling and Structure

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Title Ethnic India: A Genomic View, With Special Reference to Peopling and Structure
 
Creator Basu, Analabha
Mukherjee, Namita
Roy, Sangita
Sengupta, Sanghamitra
Banerjee, Sanat
Chakraborty, Madan
Dey, Badal
Roy, Monami
Roy, Bidyut
Bhattacharyya, Nitai P
Roychoudhury, Susanta
Majumder, Partha P
 
Subject Molecular & Human Genetics
 
Description We report a comprehensive statistical analysis of data on 58 DNA markers (mitochondrial [mt], Y-chromosomal, and
autosomal) and sequence data of the mtHVS1 from a large number of ethnically diverse populations of India. Our
results provide genomic evidence that (1) there is an underlying unity of female lineages in India, indicating that the
initial number of female settlers may have been small; (2) the tribal and the caste populations are highly
differentiated; (3) the Austro-Asiatic tribals are the earliest settlers in India, providing support to one
anthropological hypothesis while refuting some others; (4) a major wave of humans entered India through the
northeast; (5) the Tibeto-Burman tribals share considerable genetic commonalities with the Austro-Asiatic tribals,
supporting the hypothesis that they may have shared a common habitat in southern China, but the two groups of
tribals can be differentiated on the basis of Y-chromosomal haplotypes; (6) the Dravidian tribals were possibly
widespread throughout India before the arrival of the Indo-European-speaking nomads, but retreated to southern
India to avoid dominance; (7) formation of populations by fission that resulted in founder and drift effects have left
their imprints on the genetic structures of contemporary populations; (8) the upper castes show closer genetic
affinities with Central Asian populations, although those of southern India are more distant than those of northern
India; (9) historical gene flow into India has contributed to a considerable obliteration of genetic histories of
contemporary populations so that there is at present no clear congruence of genetic and geographical or
sociocultural affinities.
 
Date 2003
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1192/1/32_GR_2003.pdf
Basu, Analabha and Mukherjee, Namita and Roy, Sangita and Sengupta, Sanghamitra and Banerjee, Sanat and Chakraborty, Madan and Dey, Badal and Roy, Monami and Roy, Bidyut and Bhattacharyya, Nitai P and Roychoudhury, Susanta and Majumder, Partha P (2003) Ethnic India: A Genomic View, With Special Reference to Peopling and Structure. Genome Res., 13 (10). pp. 2277-2290.
 
Relation http://dx.doi.org/10.1101/gr.1413403
http://www.eprints.iicb.res.in/1192/