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Association of Deletion in the Chromosomal 8p21.3-23 Region with the Development of Invasive head & Neck Squamous Cell Carcinoma in Indian Patients

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Title Association of Deletion in the Chromosomal 8p21.3-23 Region with the Development of Invasive head & Neck Squamous Cell Carcinoma in Indian Patients
 
Creator Bhattacharya, N
Tripathi, A
Dasgupta, S
Sabbir, Md. Golam
Roy, A
Sengupta, A
Roy, B
Roychoudhury, Susanta
Panda, Chinmay Kumar
 
Subject Molecular & Human Genetics
 
Description The karyotypes of the HNSCC tumours are complex
often near triploid and are composed of multiple numerical
and structural abnormalities of the chromosomes3 .
Cytogenetic studies have identified deletions in several
chromosomal arms e.g., 3p, 4p, 8p21-pter, 9p13-p23,
18q22-qter etc., and also centromeric breakage in several
chromosomes necessary for HNSCC development4.
Allelotyping studies (using microsatellite markers)
of HNSCC have identified >25 per cent LOH in several
chromosomal regions e.g., 3p, 4q, 6p, 8p, 9p, 11q etc.5,6 .
Among these regions, the deletions in 4q, 6p, 8p/q are
proposed to be associated with the development of
invasive HNSCC tumours5. The deletion mapping of
HNSCC tumours by different investigators have
identified several regions in chr.8p e.g., 8p23, 8p22,
8p21 and 8p12, which might harbour candidate TSGs7.
But there is ambiguity in the localization of the minimum
common deleted region among the different studies8,9.
Also there is uncertainty about the timing of these
deletions during the progression of the tumour7,10. El-
Naggar et al10 have shown that deletions in 8p21 and
8p22 regions were associated with early tumourigenesis
of oral and laryngeal squamous cell carcinomas,
whereas according to Califano et al5 deletions in the
8p22 and 8q21.1-21.2 regions might be necessary for
the development of invasive HNSCC tumours. Besides
LOH, MA is detected in different cancers, and it may
represent a form of genomic instability11. In HNSCC
tumours, the occurrence of MAs in the Indian patient
population has been shown to be high compared to the
Western patient population12. Recently, we have
detected high frequencies (16-28%) of MA in and
around the two high LOH regions of chr.3 in primary
HNSCC, which indicate the importance of MA in the
development of this tumour13.
 
Date 2003
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1195/1/42_IJMR_Free_2003.pdf
Bhattacharya, N and Tripathi, A and Dasgupta, S and Sabbir, Md. Golam and Roy, A and Sengupta, A and Roy, B and Roychoudhury, Susanta and Panda, Chinmay Kumar (2003) Association of Deletion in the Chromosomal 8p21.3-23 Region with the Development of Invasive head & Neck Squamous Cell Carcinoma in Indian Patients. INDIAN JOURNAL OF MEDICAL RESEARCH , 118. pp. 77-85.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/1195/