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Anticlastogenic Effects of Black Tea (World blend) and Its two Active Polyphenols Theaflavins and Thearubigins in Vivo in Swiss Albino Mice

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Title Anticlastogenic Effects of Black Tea (World blend) and Its two Active Polyphenols Theaflavins and Thearubigins in Vivo in Swiss Albino Mice
 
Creator Gupta, S
Chaudhuri, T
Ganguly, D K
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description This study investigated the inhibition of cyclophosphamide (CP) and dimethylbenz(a)anthracene
(DMBA) induced genetic damage by black tea (World blend) and its two active polyphenols theaflavins
(TF) and thearubigins (TR) in Swiss albino mice as measured by chromosome aberrations (CA) and
sister chromatid exchanges (SCE). Three different concentrations (5, 10 and 20%) of tea and a single
dose of TF and TR were tested for their anticlastogenic effects against DMBA (50 mg/kg body weight)
and CP (20 mg/kg for CA and 10 mg/kg for SCE). A significant decrease in CA was observed in all the
three concentrations of tea extract plus DMBA treated groups when compared with the respective DMBA
treated group alone. Similarly a significant decrease in CA was observed in all the three concentrations
of tea extracts plus CP treated series when compared with the group treated with CP alone. In SCE assay,
a significant decrease in SCE was observed in 5, 10 and 20% black tea extract plus CP and 10 and 20%
tea extracts plus DMBA treated groups when compared with the CP or DMBA treated group alone. In
the single dose of TF and TR treated groups a significant decrease in both CA and SCE was observed
in both the TF and TR plus both the carcinogen treated groups when compared with their positive controls.
The protective effects of black tea extracts were more significant than that of its two polyphenols.
This study indicates that both black tea and its active polyphenols TF and TR have significant
anticlastogenic effects in bone marrow cells of mice.
 
Date 2001
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1200/1/Life_Sciences_69_(2001).pdf
Gupta, S and Chaudhuri, T and Ganguly, D K and Giri, Ashok K (2001) Anticlastogenic Effects of Black Tea (World blend) and Its two Active Polyphenols Theaflavins and Thearubigins in Vivo in Swiss Albino Mice. Cellular and Molecular Life Sciences (CMLS), 69. pp. 2735-2744.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/1200/