Record Details

Chromosomal Aberrations in Arsenic-Exposed Human Populations: A Review With Special Reference to a Comprehensive Study in West Bengal, India

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Chromosomal Aberrations in Arsenic-Exposed
Human Populations: A Review With Special
Reference to a Comprehensive Study in West
Bengal, India
 
Creator Mahata, Julie
Chaki, Moumita
Ghosh, Pritha
Das, J K
Baidya, K
Roy, Kunal
Natarajan, A T
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description For centuries arsenic has played an important role
in science, technology, and medicine. Arsenic for its environmental pervasiveness has gained unexpected entrance to the human body through food, water and air, thereby posing a great threat to public health due to its toxic effect and carcinogenicity. Thus, in modern scenario arsenic is synonymous with “toxic” and is documented as a paradoxical human carcinogen, although its mechanism of induction of neoplasia remains elusive. To assess the risk from environmental and occupational exposure of arsenic, in vivo cytogenetic assays have been conducted
in arseniasis-endemic areas of the world using chromosomal
aberrations (CA) and sister chromatid exchanges (SCE)
as biomarkers in peripheral blood lymphocytes. The primary
aim of this report is to critically review and update the existing in vivo cytogenetic studies performed on arsenic-exposed populations around the world and compare the results on CA and SCE from our own study, conducted in arsenic-endemic villages of North 24 Parganas (district) of West Bengal, India from 1999 to 2003. Based on a structured questionnaire, 165 symptomatic (having arsenic induced skin lesions) subjects were selected as the exposed cases consuming water having a mean arsenic content
of 214.96 Ìg/l. For comparison 155 age-sex matched control
subjects from an unaffected district (Midnapur) of West
Bengal were recruited. Similar to other arsenic exposed populations our population also showed a significant difference (P ! 0.01) in the frequencies of CA and SCE between the cases and control group. Presence of substantial chromosome damage in lymphocytes in the exposed population predicts an increased future carcinogenic risk by this metalloid.
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1203/1/Mahata_et_al[1].%2C_2004_review_(Cto.Genom.Res.).pdf
Mahata, Julie and Chaki, Moumita and Ghosh, Pritha and Das, J K and Baidya, K and Roy, Kunal and Natarajan, A T and Giri, Ashok K (2004) Chromosomal Aberrations in Arsenic-Exposed Human Populations: A Review With Special Reference to a Comprehensive Study in West Bengal, India. Cytogenet Genome, 104. pp. 359-364.
 
Relation http://dx.doi.org/10.1159/000077516
http://www.eprints.iicb.res.in/1203/