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Precancerous and Non-Cancer Disease Endpoints of Chronic Arsenic Exposure: The Level of Chromosomal Damage and XRCC3 T241M Polymorphism

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Title Precancerous and Non-Cancer Disease Endpoints of Chronic Arsenic Exposure: The Level of Chromosomal Damage and XRCC3 T241M Polymorphism
 
Creator Kundu, Manjari
Ghosh, Pritha
Mitra, Sahita
Das, J K
Sau, T J
Banerjee, Saptarshi
States, J. Christopher
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description Genetic variants are expected to play an important role in arsenic susceptibility. Our previous study
revealed de.cient DNA repair capacity to be a susceptibility factor for arsenicism. T241M polymorphism
in XRCC3 (a homologous recombination repair pathway gene) is widely studied for its association with
several cancers. We have investigated the association of XRCC3 T241M polymorphism with arsenicinduced
precancerous and non-cancer disease outcomes. The present study evaluated the association
of T241M polymorphism with arsenic-induced skin lesions, peripheral neuropathy (neurodegenerative
changes), conjunctivitis and other ocular diseases. A case-control study was conducted in West
Bengal, India, involving 206 cases with arsenic-induced skin lesions and 215 controls without arsenicinduced
skin lesions having similar arsenic exposure. XRCC3T241Mpolymorphism was determined using
conventional PCR-sequencing method. Chromosomal aberration assay, arsenic-induced neuropathy and
ocular diseases were also evaluated. The data revealed that presence of at least one Met allele (Met/Met
or Thr/Met) was protective towards development of arsenic-induced skin lesions [OR = 0.45, 95% CI:
0.30–0.67], peripheral neuropathy [OR = 0.49; 95%CI: 0.30–0.82] and conjunctivitis [OR = 0.60; 95%CI:
0.40–0.92]. A signi.cant correlation was also observed between protective genotype and decreased frequency
of chromosomal aberrations. Thus the results indicate the protective role of Met allele against
the arsenic-induced skin lesions, chromosomal instability, peripheral neuropathy and conjunctivitis.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1204/1/Kundu_et_al_(2011).pdf
Kundu, Manjari and Ghosh, Pritha and Mitra, Sahita and Das, J K and Sau, T J and Banerjee, Saptarshi and States, J. Christopher and Giri, Ashok K (2011) Precancerous and Non-Cancer Disease Endpoints of Chronic Arsenic Exposure: The Level of Chromosomal Damage and XRCC3 T241M Polymorphism. Mutation Research, 706. pp. 7-12.
 
Relation http://dx.doi.org/10.1016/j.mrfmmm.2010.10.004
http://www.eprints.iicb.res.in/1204/