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Penicillin Binding Proteins of Vibrio Cholerae

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Title Penicillin Binding Proteins of Vibrio Cholerae
 
Creator Sengupta, Tapas K
Chatterjee, Anadi N
Das, Jyotirmoy
 
Subject Infectious Diseases and Immunology
 
Description Eleven penicillin binding proteins (PBPs) of Vibrio cholerae have been identified
using [ ‘251] labelled p-hydroxybenzyl penicillin (PenX). These proteins are localised
in the inner membrane and have molecular weights ranging from 97,000 to 22,000.
Neutral hydroxylamine released the labelled PenX from the PBPs and pretreatment
with cold benzyl penicillin inhibited labelling completely. The PBP 4 is the most
sensitive target for cephaloridine and aztreonam. Cephaloridine also binds to
three other high molecular weight PBPs, 1, 2 and 3. Aztreonam, in addition to
PBP 4, has affinity for another low molecular weight PBP, PBP 7. Mecillinam
has affinity for PBPs 1, 4 and 11.
 
Publisher Elsevier
 
Date 1990
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1209/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS__171(_3)_1175%2D1181;1990[13].pdf
Sengupta, Tapas K and Chatterjee, Anadi N and Das, Jyotirmoy (1990) Penicillin Binding Proteins of Vibrio Cholerae. Biochemical and Biophysical Research Communications, 171 (3). pp. 1175-1181.
 
Relation http:..dx.doi.org/10.1016/0006-291X(90)90808-Z
http://www.eprints.iicb.res.in/1209/