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Enhanced Frequency of Micronuclei in Individuals Exposed to Arsenic Through Drinking Water in West Bengal, India

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Title Enhanced Frequency of Micronuclei in Individuals Exposed
to Arsenic Through Drinking Water in West Bengal, India
 
Creator Basu, A
Mahata, Julie
Roy, A K
Sarkar, J N
Poddar, G
Nandy, A K
Sarkar, P K
Dutta, P K
Banerjee, A
Das, M
Ray, Kunal
Roychoudhury, Susanta
Natarajan, A T
Nilsson, R
Giri, Ashok K
 
Subject Molecular & Human Genetics
 
Description InWest Bengal, India arsenic in ground water has been found to be above the maximum permissible limit in seven districts
covering an area of 37,493 km2. In the present study, evaluation of the micronuclei (MN) formation in oral mucosa cells,
urothelial cells and peripheral blood lymphocytes was carried out in the symptomatic individuals exposed to arsenic through
drinking water. Forty five individuals with cutaneous signs of arsenicism from four affected districts (368.11�g/l of As in
drinking water) were considered as the exposed group and 21 healthy individuals with no symptoms of arsenic poisoning and
residing in two unaffected districts (5.49�g/l of As) were considered as controls. The exposed and control groups had similar
age distribution and socioeconomic status. Standardised questionnaires were utilised and medical examination was conducted
to ascertain exposure history, sociodemographic characteristics, diet, health, medication, addiction and chief symptoms in the
study participants. Arsenic exposure was confirmed by measuring the arsenic content in the drinking water, nails, hair and
urine samples from the volunteers. Arsenic contents in the urine, nail and hair in the exposed group were 24.45�g/l, 12.58 and
6.97�g/g, respectively which were significantly high in comparison to corresponding control group values of 4.88�g/l, 0.51
and 0.34�g/g, respectively. Exposed individuals showed a statistically significant increase in the frequency of MN in oral
mucosa, urothelial cells and lymphocytes (5.15, 5.74 and 6.39/1000 cells, respectively) when compared with the controls (0.77,
0.56 and 0.53/1000 cells, respectively). Thus, the above results indicate that the symptomatic individuals exposed to arsenic
through drinking water in this region have significant cytogenetic damage. © 2002 Elsevier Science B.V.
 
Date 2002
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1217/1/Mut.Res.516(MN).pdf
Basu, A and Mahata, Julie and Roy, A K and Sarkar, J N and Poddar, G and Nandy, A K and Sarkar, P K and Dutta, P K and Banerjee, A and Das, M and Ray, Kunal and Roychoudhury, Susanta and Natarajan, A T and Nilsson, R and Giri, Ashok K (2002) Enhanced Frequency of Micronuclei in Individuals Exposed to Arsenic Through Drinking Water in West Bengal, India. Mutation Research, 516. pp. 29-40.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/1217/