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Immunomodulatory Stimulation of an Invertebrate Circulatory Lectin by its Haptenic Molecules of Pathogenic Origin

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Title Immunomodulatory Stimulation of an Invertebrate Circulatory Lectin by its Haptenic Molecules of Pathogenic Origin
 
Creator Basu Sarbadhikary, Sujata
Bhadra, Ranjan
 
Subject Infectious Diseases and Immunology
 
Description 2-keto-3-deoxy octonate and I~-
glycerophosphate two important bacterial cell
wall constituent molecules, haptenic in nature
to an invertebrate (crab) circulatory lectin, carcinoscorpin,
gave lectin induction after immunization
of the crab, Carcinoscorpius rotundacauda.
With the exception of erythrocyte, no
other sialoglycoconjugate-containing substances
(mucin, fetuin) sialodisaccharide
O-[N-acetylneuraminyl-(2 ---> 6)2-acetamido-2-
deoxy galactitol] and free sialic acid were effective
in lectin induction. This induction of
circulatory lectin failed to appear when, concanavalin
A, epinephrine, cytochalasin B,
methyl-o~-I>mannoside and bovine serum albumin
were used for immunization. But mechanical
injury to crabs were extremely effective
in such lectin induction by live crabs. LPS
is lethal if used for immunization. The immunoregulatory
induction of the circulatory lectin
by pathogen-originated cell wall constituent
molecules and mechanical injury may be considered
as a humoral immune response.
 
Date 1990
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1222/1/DEVELOPMENTAL_AND_COMPARATIVE_IMMUNOLOGY__14(_1)___31%2D38__;1990[6].pdf
Basu Sarbadhikary, Sujata and Bhadra, Ranjan (1990) Immunomodulatory Stimulation of an Invertebrate Circulatory Lectin by its Haptenic Molecules of Pathogenic Origin. Developmental and Comparative ImmunologY, 14 (1). pp. 31-38.
 
Relation http://dx.doi.org/ 10.1016/0145-305X(90)90005-Y
http://www.eprints.iicb.res.in/1222/