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Technetium-99m Amino Acid Chelates : Correlation of Their Physico-Chemical and Physiological Parameters . Part I .

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Title Technetium-99m Amino Acid Chelates :
Correlation of Their Physico-Chemical
and Physiological Parameters . Part I .
 
Creator Chakravarty, Munna
Sanyal, Soma
Banerjee, Somenath
 
Subject Infectious Diseases and Immunology
 
Description Ten a-aminocarboxylic acids were chelated with 99'"'Tc and purified by sephadex gel chromatography .
Their hepatobiliary and renal excretion patterns were determined in rats . It was observed that lipophilicity
of these chelates is the only determinant in governing their hepatobiliary excretion, whereas their renal
excretion is dependent on some other factors in addition to lipophilicity . Depression of renal excretion in
presence of probenecid indicated an interaction of renal tubular transport enzymes with these chelates,
which was explained from their hexacoordinated dioxotechnetium (V) chelate structure (II) .
 
Publisher Elsevier
 
Date 1990
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1223/1/JOURNAL_OF_INORGANIC_BIOCHEMISTRY__39_(_1)_43%2D57;1990[40].pdf
Chakravarty, Munna and Sanyal, Soma and Banerjee, Somenath (1990) Technetium-99m Amino Acid Chelates : Correlation of Their Physico-Chemical and Physiological Parameters . Part I . Journal of Inorganic Biochemistry, 39 (1). pp. 43-57.
 
Relation http://dx.doi.org/10.1016/0162-0134(90)80014-O
http://www.eprints.iicb.res.in/1223/