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Synthesis of Novel Heme-Interacting Acridone Derivatives to Prevent Free Heme-Mediated Protein Oxidation and Degradation.

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Title Synthesis of Novel Heme-Interacting Acridone Derivatives to Prevent Free Heme-Mediated Protein Oxidation and Degradation.
 
Creator Pal, Chinmay
Kundu, Milan Kumar
Bandyopadhyay, Uday
Adhikari, Susanta
 
Subject Infectious Diseases and Immunology
 
Description Heme is an important prosthetic molecule for various hemoproteins and serves important function in living
aerobic organisms. But degradation of hemoprotein, for example, hemoglobin during different pathological
conditions leads to the release of heme, which is very toxic as it induces oxidative stress and
inflammation due to its pro-oxidant nature. Thus, synthesis of compound that will detoxify free heme
by interacting with it would be fruitful for the management of heme-induced pathogenesis. Here, we
report the synthesis of a novel natural product arborinine and some other acridone derivatives, which
interact with free heme. These acridones in vitro block heme-mediated protein oxidation and degradation,
markers for heme-induced oxidative stress
 
Publisher Elsevier
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1235/1/BIOORGANIC_%26_MEDICINAL_CHEMISTRY_LETTERS___21(_12)3563%2D3567;2011[75].pdf
Pal, Chinmay and Kundu, Milan Kumar and Bandyopadhyay, Uday and Adhikari, Susanta (2011) Synthesis of Novel Heme-Interacting Acridone Derivatives to Prevent Free Heme-Mediated Protein Oxidation and Degradation. Bioorganic & Medicinal Chemistry Letters, 21 (12). pp. 3563-3567.
 
Relation http://dx.doi.org/10.1016/j.bmcl.2011.04.127
http://www.eprints.iicb.res.in/1235/