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Search for Safe Antineoplastic and Anti Inflammatory Bioactive Compounds from Indian Traditional Medicinal Plants

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Title Search for Safe Antineoplastic and Anti Inflammatory Bioactive Compounds from Indian Traditional Medicinal Plants
 
Creator Nandi, Debkumar
 
Subject Chemistry
Drug Development/Diagnostics & Biotechnology
 
Description This chapter deals with the review on the natural sources, biological activity, chemical
and biosynthesis of flavonoid glycosides. One of the major classes of secondary plant
metabolites are flavonoid glycosides. More than 8000 varieties of flavonoids have been
isolated from various plants and, many of them are responsible for the attractive colour of
flower, fruits and leaves. Distributions of flavonoids either in free from or as
glycosides in some common food have been listed and also depict some isolated
flavonoid glycosides with their natural sources as presented in literature. The diversity in
chemical structure of flavonoids leads them to a wide range of biological activities. In
plants, their function seems to be linked to protection against ultraviolet radiation,
microbial invasion and both insect and mammalian herbivores. Their actions in humans
have been the subject of extensive research. They have been described to possess
numerous biological activities like anti-oxidative effects, leukocyte immobilization,
interaction with other enzyme systems etc., which are all described elaborately.
Biosynthetic route of any compound is important as it will help to visualize the chemical
synthesis. The flavonoid biosynthetic pathway and its regulation have been well studied in
plants and many enzymes required for the production of different favonoid classes have
been characterized. Bio synthetic pathway to flavonoids as appearing in the literature have
been described in this chapter. Lastly, the chemical synthetic root and recent development
on total synthesis of flavonoid glycosides in particular kaempferitine synthesis have been
described.
 
Date 2009
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1241/1/Thesis_Total[1].pdf
Nandi, Debkumar (2009) Search for Safe Antineoplastic and Anti Inflammatory Bioactive Compounds from Indian Traditional Medicinal Plants. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1241/