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Studies on The Synthesis of Modified Nucleosides Derived from Carbohydrate Based Chiral Precursors

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Title Studies on The Synthesis of Modified Nucleosides Derived
from Carbohydrate Based Chiral Precursors
 
Creator Ghosh, Ramprasad
 
Subject Chemistry
 
Description The area of carbocyclic nucleosides (carbanucleosides) has developed after the isolation of
(-)-aristeromycin3 (1) and (-)-neplanocin A25 (2) from natural sources. Many of the carbocyclic
nucleosides, arising from the replacement of the furanose ring oxygen by a carbon atom, exhibit
interesting antiviral properties against herpes simplex virus (HSV 1 and 2), human
cytomegalovirus26, hepatitis B virus,27 and human immunodeficiency virus5, 28 (HIV). One of the
reasons for the remarkable activities of this class of nucleosides is their better chemical as well
as metabolic stability against various chemicals and enzymes29. Among various analogues,
carbovir5 (3) and abacavir30 (4) are particularly interesting and the latter is currently being
evaluated in HIV infected patients.
 
Date 2010
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1292/1/Ramaprasad_pdf.pdf
Ghosh, Ramprasad (2010) Studies on The Synthesis of Modified Nucleosides Derived from Carbohydrate Based Chiral Precursors. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1292/