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Complete Nucleotide Sequence of a Quinolone Resistance Gene (qnrS2) Carrying Plasmid of Aeromonas Hydrophila Isolated from Fish.

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Title Complete Nucleotide Sequence of a Quinolone Resistance Gene (qnrS2) Carrying Plasmid of Aeromonas Hydrophila Isolated from Fish.
 
Creator Majumdar, Tanmay
Das, Bhabatosh
Bhadra, Rupak K
Damc, Bomba
Mazumder, Shibnath
 
Subject Infectious Diseases and Immunology
 
Description Aeromonas hydrophila strain AO1 isolated from an infected fish was found to be resistant to
several quinolones. A plasmid isolated from the strain AO1, termed pBRST7.6, was cloned
and sequenced and shown to be 7621 bp in length with a GC content of 60%. Further
analysis confirmed that it contained a gene with 100% identity to qnrS2 genes described
in plasmids associated with other Aeromonas species, the product of which usually confers
increased resistance to quinolones. The plasmid backbone contained a replication initiation
module (repA repC) belonging to the IncQ-family and two genes (mobC and mobB), the
products of which are putatively involved in plasmid mobilization. Putative iteron-based
origin of replication and characteristic oriT like sequences were also present in the plasmid.
The result suggests that Aeromonas spp. carrying plasmids with quinolone resistance genes
are potential reservoirs of antimicrobial resistance determinants in the environment.
 
Publisher Elsevier
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1333/1/PLASMID__66_(_2_)_79%2D84;2011[59].pdf
Majumdar, Tanmay and Das, Bhabatosh and Bhadra, Rupak K and Damc, Bomba and Mazumder, Shibnath (2011) Complete Nucleotide Sequence of a Quinolone Resistance Gene (qnrS2) Carrying Plasmid of Aeromonas Hydrophila Isolated from Fish. Plasmid, 66 (2). pp. 79-84.
 
Relation http://dx.doi.org/10.1016/j.plasmid.2011.05.001
http://www.eprints.iicb.res.in/1333/