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Sub-Optimal dose of Sodium Antimony Gluconate (SAG)-Diperoxovanadate Combination Clears Organ Parasites from BALB/c Mice Infected with Antimony Resistant Leishmania Donovani by Expanding Antileishmanial T-Cell Repertoire and Increasing IFN-c to IL-10 Ratio

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Title Sub-Optimal dose of Sodium Antimony Gluconate (SAG)-Diperoxovanadate
Combination Clears Organ Parasites from BALB/c Mice Infected with Antimony
Resistant Leishmania Donovani by Expanding Antileishmanial T-Cell Repertoire
and Increasing IFN-c to IL-10 Ratio
 
Creator Haldar, Arun Kumar
Banerjee, Subha
Naskar, Kshudiram
Kalita, Diganta
Islam, Nashreen S
Roy, Syamal
 
Subject Infectious Diseases and Immunology
 
Description We demonstrate that the combination of sub-optimal doses of Sodium Antimony Gluconate (SAG) and
the diperoxovanadate compound K[VO(O2)2(H2O)], also designated as PV6, is highly effective in combating
experimental infection of BALB/c mice with antimony resistant (SbR) Leishmania donovani (LD) as evident
from the significant reduction in organ parasite burden where SAG is essentially ineffective.
Interestingly, such treatment also allowed clonal expansion of antileishmanial T-cells coupled with
robust surge of IFN-c and concomitant decrease in IL-10 production. The splenocytes from the treated
animals generated significantly higher amounts of IFN-c inducible parasiticidal effector molecules like
superoxide and nitric oxide as compared to the infected group. Our study indicates that the combination
of sub-optimal doses of SAG and PV6 may be beneficial for the treatment of SAG resistant visceral leishmaniasis
patients.
 
Publisher Elsevier
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1363/1/EXPERIMENTAL_PARASITOLOGY___122_(2)145%2D154;2009[68].pdf
Haldar, Arun Kumar and Banerjee, Subha and Naskar, Kshudiram and Kalita, Diganta and Islam, Nashreen S and Roy, Syamal (2009) Sub-Optimal dose of Sodium Antimony Gluconate (SAG)-Diperoxovanadate Combination Clears Organ Parasites from BALB/c Mice Infected with Antimony Resistant Leishmania Donovani by Expanding Antileishmanial T-Cell Repertoire and Increasing IFN-c to IL-10 Ratio. Experimental Parasitology, 122 (2). pp. 145-154.
 
Relation http://dx.doi.org/10.1016/j.exppara.2009.02.001
http://www.eprints.iicb.res.in/1363/