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Mast Cell Stabilization and Antihistaminic Potentials of Curculigo Orchioides Rhizomes

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Title Mast Cell Stabilization and Antihistaminic Potentials
of Curculigo Orchioides Rhizomes
 
Creator Venkatesha, P
Mukherjee, Pulok K
Kumar N, Satheesh
Nema, Neelesh K.
Bandyopadhyay, Arun
Fukuic, Hiroyuki
Mizuguchi, Hiroyuki
 
Subject Cell Biology & Physiology
 
Description Aim of the study: To investigate the mast cell stabilization and antihistaminic activities of the rhizomes of
Curculigo orchioides (COR). Extract of Curculigo orchioides Gaertn. (Fam. Amaryllidaceae) has been reported
to possess immunostimulant, and anti-inflammatory potentials. In Indian traditional system of medicine
it is also used as anti-asthmatic and anti-inflammatory.
Materials and methods: Estimation of histamine release is key parameter for evaluating any target for its
anti-allergic potential. The stabilization potential of the alcoholic extract of COR (100–400 mg/kg) against
mast cell degranulation was studied on isolated mice peritoneal mast cells. The antihistaminic activity
was performed by determining the mortality rate of mice upon exposure to compound 48/80 and effect
on inhibition of histamine release upon degranulation.
Results: The raised number of intact mast cells intimates that the COR stabilized the mast cell degranulation
(60.96±1.96%) and percentage antihistaminic potential of the extract (63.58±1.8 inhibition at dose
of 400 mg/kg) and it virtues further work towards the isolation of phytoconstituents from this plant.
Conclusion: This finding provides evidence that COR inhibits mast cell-derived immediate-type allergic
reactions and mast cell degranulation.
 
Publisher Elsevier
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1368/1/JOURNAL_OF_ETHNOPHARMACOLOGY___126_(3)_434%2D436;2009[2].pdf
Venkatesha, P and Mukherjee, Pulok K and Kumar N, Satheesh and Nema, Neelesh K. and Bandyopadhyay, Arun and Fukuic, Hiroyuki and Mizuguchi, Hiroyuki (2009) Mast Cell Stabilization and Antihistaminic Potentials of Curculigo Orchioides Rhizomes. Journal of Ethnopharmacology, 126 (3). pp. 434-436.
 
Relation http://dx.doi.org/10.1016/j.jep.2009.09.019
http://www.eprints.iicb.res.in/1368/