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Reduced NADH Coenzyme Q Dehydrogenase Activity in Platelets of Parkinson's Disease, but not Parkinson plus Patients, from an Indian Population.

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Title Reduced NADH Coenzyme Q Dehydrogenase Activity in Platelets of Parkinson's Disease, but not Parkinson plus Patients, from an Indian Population.
 
Creator Varghese, Merina
Pandey, Mritunjay
Samanta, Ananda
Gangopadhyay, Prasanta Kumar
Mohanakumar, K P
 
Subject Cell Biology & Physiology
 
Description The observation of decline in mitochondrial electron transport chain function, specifically at complex I, in
patients with Parkinson's disease (PD) has been reported by several groups. This study investigates whether a
defect of mitochondrial function is present in the platelets of PD patients from an Indian population. We
found that the NADH dehydrogenase activity in the platelets of PD patients is lower than that in healthy ageand
gender-matched controls, while the succinate dehydrogenase activity was similar in both groups.
Furthermore, there was no change in either of the activities in patients with Parkinson plus syndrome or
atypical parkinsonism. This is the first report indicating a decline in mitochondrial function in the platelets of
PD patients from the Indian population, offering further support to the role of a mitochondrial defect in PD.
 
Publisher Elsevier
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1370/1/JOURNAL_OF_THE_NEUROLOGICAL_SCIENCES___279_(_1%2D2)_39%2D42;2009[78].pdf
Varghese, Merina and Pandey, Mritunjay and Samanta, Ananda and Gangopadhyay, Prasanta Kumar and Mohanakumar, K P (2009) Reduced NADH Coenzyme Q Dehydrogenase Activity in Platelets of Parkinson's Disease, but not Parkinson plus Patients, from an Indian Population. Journal of the Neurological Sciences, 279 (1-2). pp. 39-42.
 
Relation http://dx.doi.org/10.1016/j.jns.2008.12.021
http://www.eprints.iicb.res.in/1370/