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Methylglyoxal Induced Activation of Murine Peritoneal Macrophages and Surface Markers of T Lymphocytes in Sarcoma-180 Bearing Mice: Involvement of MAP Kinase, NF-�� Signal Transduction Pathway

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Title Methylglyoxal Induced Activation of Murine Peritoneal Macrophages and Surface Markers of T Lymphocytes in Sarcoma-180 Bearing Mice: Involvement of MAP Kinase, NF-�� Signal Transduction Pathway
 
Creator Pal, Aparajita
Bhattacharya, Iman
Bhattacharya, Kaushik
Mandal, Chitra
Ray, Manju
 
Subject Infectious Diseases and Immunology
 
Description Methylglyoxal profoundly stimulates host’s immune response against tumor cell by producing reactive
oxygen intermediates (ROI’s) and reactive nitrogen intermediates (RNI’s) [Bhattacharyya, N., Pal, A., Patra,
S., Haldar,A.K.,Roy, S.,Ray, M., 2008.Activation of macrophages and lymphocytes bymethylglyoxal against
tumor cells in the host. Int. Immunophar. 8 (11), 1503–1512]. Present study indicated that methylglyoxal
stimulates iNOS activation by p38 MAPK-NF-�� dependent pathway and ROS production by ERK and JNK
activation in sarcoma-180 tumor bearing mice. Proinflammatory cytokines, for macrophage activation,
IL-6 and IL-1� were also increased. Production of TLR 4 and TLR 9, which acts through the same signaling
pathway, were also upregulated. Hence, concluded that methylglyoxal augmented the IL-6 and IL-1�,
expression of TLR 4 and TLR 9 and produced MAPKs, important regulators of ROIs and RNIs. Methylglyoxal
treatment also increased M-CSF, an upregulator of macrophage production. CD8 and CD4 molecules,
associated with TC and TH cells respectively, were also increased. Overall methylglyoxal treatment is
important for enhancement of macrophages and lymphocyte activation or immunomodulation against
sarcoma-180 tumor
 
Publisher Elsevier
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1374/1/MOLECULAR_IMMUNOLOGY___46_(10)_2039%2D2044;2009[62].pdf
Pal, Aparajita and Bhattacharya, Iman and Bhattacharya, Kaushik and Mandal, Chitra and Ray, Manju (2009) Methylglyoxal Induced Activation of Murine Peritoneal Macrophages and Surface Markers of T Lymphocytes in Sarcoma-180 Bearing Mice: Involvement of MAP Kinase, NF-�� Signal Transduction Pathway. Molecular Immunology, 46 (10). pp. 2039-2044.
 
Relation http://dx.doi.org/10.1016/j.molimm.2009.03.014
http://www.eprints.iicb.res.in/1374/