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Experimental Osteoporosis Induced in Female Albino Rats and its Antagonism by Indian Black Scorpion (Heterometrus Bengalensis C.L.Koch) Venom.

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Title Experimental Osteoporosis Induced in Female Albino Rats and its Antagonism by Indian Black Scorpion (Heterometrus Bengalensis C.L.Koch) Venom.
 
Creator Gomes, Antony
Haldar, Subhash
Giri, Biplab
Mishra, Roshnara
Saha, Archita
Dasgupta, Shubho
Gomes, Aparna
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description The present study was designed to explore the antiosteoporosis activity of the Indian black
scorpion (Heterometrus bengalensis) venom on experimental osteoporosis female albino
rats. Sham operated control rats were designated as Gr I, Gr II animals served as osteoporosis
control, Gr III osteoporosis rats were treated with SV (1/25th of MLD), Gr IV
osteoporosis rats were treated with 1/50th of MLD of SV and Gr V osteoporosis rats were
treated with standard (calcium and vit-D3). As compared with the Gr I rats, the Gr II rats
showed typical osteoporosis changes in increased of urinary Ca2þ, PO43�, CRE, OH-P levels,
serum/plasma Ca2þ, PO4 3�, TRAP, IL1, IL6, TNFa and PTH level, bone Ca2þ, PO4 3�, Mg2þ, Zn2þ
and decreased level of serum/plasma ALP, EST and PTH, bone Naþ. In Gr III, Gr IV and Gr V
rats, the osteoporosis changes of urine, serum and bone, were significantly restored as
compared with the Gr II rats. The bone dimensions, morphology and histological changes
observed in Gr II rats were restored in Gr III, Gr IV and Gr V rats. This study confirms that
the Indian black scorpion venom may influence bone remodeling process by stimulating
bone formation and reducing bone resorption process of osteogenesis.
 
Publisher Elsevier
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1384/1/TOXICON___53_(_1)_60%2D68;2009[123].pdf
Gomes, Antony and Haldar, Subhash and Giri, Biplab and Mishra, Roshnara and Saha, Archita and Dasgupta, Shubho and Gomes, Aparna (2009) Experimental Osteoporosis Induced in Female Albino Rats and its Antagonism by Indian Black Scorpion (Heterometrus Bengalensis C.L.Koch) Venom. Toxicon, 53 (1). pp. 60-68.
 
Relation http://dx.doi.org/10.1016/j.toxicon.2008.10.011
http://www.eprints.iicb.res.in/1384/