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KMP-11 DNA Immunization Significantly Protects against L. Donovani Infection but Requires Exogenous IL-12 as an Adjuvant for Comparable Protection against L. major

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Title KMP-11 DNA Immunization Significantly Protects against L. Donovani Infection but Requires Exogenous IL-12 as an Adjuvant for Comparable Protection against L. major
 
Creator Bhaumik, Suniti
Basu, Rajatava
Sen, Subha
Naskar, Kshudiram
Roy, Syamal
 
Subject Infectious Diseases and Immunology
 
Description As vaccine potential of cross-species protection by a candidate antigen is less explored, in this study we
compared cross-specific protective efficacy of KinetoplastidMembrane Protein-11 (KMP-11) as aDNAvaccine
alone and in conjunction with exogenous IL-12 administration in experimental BALB/c model against
two most widely prevalent forms of clinical diseases caused by Leishmania major (LM) and Leishmania
donovani (LD). Whereas, KMP-11 DNA vaccination alone showed significant potential in terms of resolution
of splenic and hepatic parasite burden against virulent LD challenge, it showed considerably less
efficacy (
 
Publisher Elsevier
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1385/1/VACCINE_27(_9)__1306%2D1316;2009[102].pdf
Bhaumik, Suniti and Basu, Rajatava and Sen, Subha and Naskar, Kshudiram and Roy, Syamal (2009) KMP-11 DNA Immunization Significantly Protects against L. Donovani Infection but Requires Exogenous IL-12 as an Adjuvant for Comparable Protection against L. major. Vaccine, 27 (9). pp. 1306-1316.
 
Relation http://dx.doi.org/10.1016/j.vaccine.2008.12.053
http://www.eprints.iicb.res.in/1385/