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An Unique Specificity Of a Sialic Acid Binding Lectin Achatininh, From the Hemolymph of Achatina Fulica Snail

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Title An Unique Specificity Of a Sialic Acid Binding Lectin Achatininh, From the Hemolymph of Achatina Fulica Snail
 
Creator Mandal, Chitra
Basu, Sujata
 
Subject Infectious Diseases and Immunology
 
Description A sialic acid-binding lectin, AchatininH , from the hemolymph of Achatina
fulica snail is found to be highly specific for V-0-acetyl sialic acid.
The binding specificity of AchatininH distinguishes it from other known
sialic-acid specific lectins which usually show a broader range of specificity
for sialic acid. It is even better than crab lectin which shows specificity
for both 4- and V-0-acetylated derivatives of sialic acid. This limited
specificity of AchatininH appear to account for the fact that it agglutinates
only rabbit, rat and guineapig erythrocytes which contain V-0-acetylated
sialic acid but not horse (mainly contain 4-0-acetylated sialic acid), human,
monkey, sheep, goat and chicken erythrocytes which contain either N-acetyl
or N-glycolyl neuraminic acid but no 0-acetylated derivatives. This finding
was further supported by the potent inhibition of hemagglutination by free
9-0-acetylated neuraminic acid and by several glyco sphingolipids of human
origin having 0-acetylated sialic acid.
 
Publisher Elsevier
 
Date 1987
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1424/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS__148(_2);_1987[11].pdf
Mandal, Chitra and Basu, Sujata (1987) An Unique Specificity Of a Sialic Acid Binding Lectin Achatininh, From the Hemolymph of Achatina Fulica Snail. Biochemical and Biophysical Research Communications, 148 (2). pp. 795-801.
 
Relation http://dx.doi.org/10.1016/0006-291X(87)90946-6
http://www.eprints.iicb.res.in/1424/