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In Vitro and In Vivo Effect of Chloropromazine, Imipramine and Lithium Chloride on Monoamine Oxidase Activity in Rat Brain Mitochondria

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Title In Vitro and In Vivo Effect of Chloropromazine, Imipramine and Lithium Chloride on Monoamine Oxidase Activity in Rat Brain Mitochondria
 
Creator Nag, Maitreyi
Nandi, Namita
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Chloropromazine (CPZ) and imipramine at a concentration of 1 x 10- 3 M inhibit rat
brain mitochondrial monoamine oxidase activity in vitro by 70 and 55 % respectively,
'while lithium, even at a concentration of 0.05 M, inhibits the activity of this enzyme
'very negligibly (4%). In vivo, these drugs at a dose level of 56 mg CPZ, 76 mg
Jimipramine and 76 mg lithium chloride/Kg body wt., did not cause any observable
'variation from normal in brain mitochondrial monoamine oxidase activity.
 
Publisher Kluwer
 
Date 1987
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1428/1/Bioscience_Reports%2C_7(_9);_1987[20].pdf
Nag, Maitreyi and Nandi, Namita (1987) In Vitro and In Vivo Effect of Chloropromazine, Imipramine and Lithium Chloride on Monoamine Oxidase Activity in Rat Brain Mitochondria. Bioscience Reports, 7 (9). pp. 701-704.
 
Relation http://dx.doi.org/10.1007/BF01116862
http://www.eprints.iicb.res.in/1428/