Record Details

Decatenation of Kinetoplast DNA by an ATP-Dependent DNA Topoisomerase from the Kinetoplast Hemoflagellate Leishmania Donovani

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Decatenation of Kinetoplast DNA by an ATP-Dependent DNA
Topoisomerase from the Kinetoplast Hemoflagellate Leishmania Donovani
 
Creator Chakraborty, Asit K
Majumder, Hemanta K
 
Subject Infectious Diseases and Immunology
 
Description An enzyme from Leishmania donovani that decatenates kinetoplast DNA networks into covalently closed monomeric circles
has been isolated and characterized. The enzyme also relaxes supercoiled plasmid pBR322. The decatenation and relaxation reactions
both require ATP and Mg 2-. In both reactions the formation of topological isomers of unique linking numbers suggests
that the enzyme is a type II DNA topoisomerase. Both the relaxation and decatenating activities are inhibited by novobiocin at
a very high concentration
 
Publisher Elsevier
 
Date 1987
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1438/1/MOLECULAR_AND_BIOCHEMICAL_PARASITOLOGY__26_(3)_215%2D224[3].pdf
Chakraborty, Asit K and Majumder, Hemanta K (1987) Decatenation of Kinetoplast DNA by an ATP-Dependent DNA Topoisomerase from the Kinetoplast Hemoflagellate Leishmania Donovani. Molecular and Biochemical Parasitology, 26 (3). pp. 215-224.
 
Relation http://dx.doi.org/10.1016/0166-6851(87)90074-0
http://www.eprints.iicb.res.in/1438/