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Excretion of Cholera Toxin From Escherichia Coli • A Potential Oral Vaccine For Cholera

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Title Excretion of Cholera Toxin From Escherichia Coli •
A Potential Oral Vaccine For Cholera
 
Creator Dasgupta, Ujjala
Guhathakurta, Indrajit
Das, Jyotirmoy
 
Subject Molecular & Human Genetics
 
Description E~cherichia ooli strain N100 has been mutagenized by transposon mutagenesis
and mutants with a cell surface leaky phenotype have been isolated. The mutant
designated as E. coli N100::Tn5 excreted periplasmic proteins like ribonuclease
and alkaline phosphatase. When this mutant strain was transformed with
plasmids containing cloned cholera toxin genes, the toxin protein synthesized
in the cells were excreted. The potentiality of this strain as a live oral
vaccine for cholera has been discussed.
 
Publisher Elsevier
 
Date 1988
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1441/1/BIOCHEMICAL_AND_BIOPHYSICAL_RESEARCH_COMMUNICATIONS__Volume_153___Issue_3___Pages_967%2D972%2C1988[34].pdf
Dasgupta, Ujjala and Guhathakurta, Indrajit and Das, Jyotirmoy (1988) Excretion of Cholera Toxin From Escherichia Coli • A Potential Oral Vaccine For Cholera. Biochemical and Biophysical Research Communications, 153 (3). pp. 967-972.
 
Relation http://dx.doi.org/10.1016/S0006-291X(88)81322-6
http://www.eprints.iicb.res.in/1441/