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Renal Handling of Amino Acid 99mTechnetium Chelates

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Title Renal Handling of Amino Acid 99mTechnetium Chelates
 
Creator Chattopadhyay, Munna
Banerjee, Somenath
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Four amino acids-alanine, 2,3diaminopropionic acid, cystine, and cystein-and also one diamine,
ethylenediamine, were chelated with 99m-technetium FTC), and their renal excretion patterns were
studied in rabbits in the presence and absence of two renal tubular transport inhibitors, probenecid and
2,4dinitrophenol. From the depression of renal excretion for the first three amino acid chelates, in the
presence of the inhibitors, a renal tubular excretory pathway of elimination was suggested for these
compounds. The renal excretions of 99mTc-cystein and 99”Tc-ethylenediamine however, remained
undepressed under similar experimental conditions. An explanation of these observations was forwarded
from the possible chemical structures of these chelates
 
Publisher Elsevier
 
Date 1988
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1455/1/JOURNAL_OF_INORGANIC_BIOCHEMISTRY__Volume_34___Issue_1___Pages_25%2D40%2C1988[26].pdf
Chattopadhyay, Munna and Banerjee, Somenath (1988) Renal Handling of Amino Acid 99mTechnetium Chelates. Journal of Inorganic Biochemistry, 34 (1). pp. 25-40.
 
Relation http://dx.doi.org/10.1016/0162-0134(88)85015-3
http://www.eprints.iicb.res.in/1455/