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Role of Mannose/N-Acetylglucosamine Receptors in Blood Clearance and Cellular Attachment of Leishmania Donovani

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Title Role of Mannose/N-Acetylglucosamine Receptors in Blood Clearance and Cellular Attachment of Leishmania Donovani
 
Creator Chakraborty, Prasanta
Das, Pijush K
 
Subject Infectious Diseases and Immunology
 
Description The effects of glycoprotei~ and neoglycoproteins specific for liver and macrophage membrane lectins on both the cellular attachment
and the clearance of Leishmania donovani from hamster blood were investigated. Although the inhibition pattern of in
vitro cellular attachment studies indicates the involvement of both galactose and mannose/N-acetylglucosamine receptors, the in
vivo blood clearance of the parasites was inhibited only by glycoproteins and neoglycoproteins specific for m.r.nnose/N-acetylglucosamine
receptors. The inhibitory effects on blood clearance were abolished by pretreating the parasites with tunicamycin, an
inhibitor of protein glycosylation. These results indicate that the mannose/N-acetylghicosandne hepatic lectin recognizes specific
sugars on the parasite Surface and is important to the promastigote during the early stages of infection.
 
Publisher Elsevier
 
Date 1988
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1456/1/MOLECULAR_AND_BIOCHEMICAL_PARASITOLOGY__Volume_28___Issue_1___Pages_55%2D62;1988[59].pdf
Chakraborty, Prasanta and Das, Pijush K (1988) Role of Mannose/N-Acetylglucosamine Receptors in Blood Clearance and Cellular Attachment of Leishmania Donovani. Molecular and Biochemical Parasitology, 28 (1). pp. 55-62.
 
Relation http://dx.doi.org/10.1016/0166-6851(88)90180-6
http://www.eprints.iicb.res.in/1456/