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A Facile Synthesis of PEG-Coated Magnetite (Fe3O4) Nanoparticles and Their Prevention of the Reduction of Cytochrome C

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Title A Facile Synthesis of PEG-Coated Magnetite (Fe3O4) Nanoparticles
and Their Prevention of the Reduction of Cytochrome C
 
Creator Mukhopadhyay, Anindita
Joshi, Nidhi
Chattopadhyay, Krishnananda
De, Goutam
 
Subject Structural Biology & Bioinformatics
 
Description We report here a facile and green synthetic
approach to prepare magnetite (Fe3O4) nanoparticles (NPs)
with magnetic core and polyethylene glycol (PEG) surface
coating. The interaction of the bare and PEG-coated Fe3O4
NPs with cytochrome c (cyt c, an important protein with
direct role in the electron transfer chain) is also reported in
this study. With ultrasonication as the only peptization method
and water as the synthesis medium, this method is easy, fast,
and environmentally benign. The PEG coated NPs are highly
water dispersible and stable. The bare NPs have considerable
magnetism at room temperature; surface modification by PEG
has resulted in softening the magnetization. This approach can very well be applicable to prepare biocompatible, surface-modified
soft magnetic materials, which may offer enormous utility in the field of biomedical research. Detailed characterizations including
XRD, FTIR, TG/DTA, TEM, and VSM of the PEG-coated Fe3O4 NPs were carried out in order to ensure the future applicability
of this method. Although the interaction of bare NPs with cyt c shows reduction of the protein, efficient surface modification by
PEG prevents its reduction
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1476/1/ACS_APPLIED_MATERIALS_%26_INTERFACES__4(_1)142%2D149;2012[76].pdf
Mukhopadhyay, Anindita and Joshi, Nidhi and Chattopadhyay, Krishnananda and De, Goutam (2012) A Facile Synthesis of PEG-Coated Magnetite (Fe3O4) Nanoparticles and Their Prevention of the Reduction of Cytochrome C. ACS Applied Materials & Interfaces, 4 (1). pp. 142-149.
 
Relation http://dx.doi.org/10.1021/am201166m
http://www.eprints.iicb.res.in/1476/