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Curcumin Heals Indomethacin-Induced Gastric Ulceration by Stimulation of Angiogenesis and Restitution of Collagen Fibers via VEGF and MMP-2 Mediated Signaling

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Title Curcumin Heals Indomethacin-Induced Gastric
Ulceration by Stimulation of Angiogenesis
and Restitution of Collagen Fibers via VEGF
and MMP-2 Mediated Signaling
 
Creator Sharma, Anamika Vivek
Ganguly, Krishnendu
Paul, Sumit
Maulik, Nilanjana
Swarnakar, Snehasikta
 
Subject Drug Development/Diagnostics & Biotechnology
 
Description Aim:We examined the molecular mechanism of curcumin in a preventive and therapeutic model of indomethacininduced
gastric ulceration with regard to angiogenic processes. Results: Disrupted blood vessels, reduced collagen
matrices, and significant (60%) injury to mucosal cells were observed during ulceration. In addition, ulcerated
tissues exhibited decreased matrix metalloproteinase (MMP)-2 and vascular endothelial growth factor (VEGF)
expression in blood vessels. Interestingly, curcumin blocked ulceration by induction of collagenization and angiogenesis
in gastric tissues via upregulation of MMP-2, membrane type (MT) 1-MMP, VEGF, and transforming
growth factor (TGF)-b at protein and messenger ribonucleic acid (mRNA) levels. To examine the angiogenic
properties of curcumin, we employed a chorioallantoic membrane model and Matrigel assay. During healing,
curcumin promoted collagenization and angiogenesis as well as enhanced MMP-2 activity via positive MT1-MMP
regulation and negative tissue inhibitor of metalloproteinase-2 regulation. Innovation: Our study demonstrates
that curcumin-mediated healing is associated with increased MMP-2, TGF-b, and VEGF expression and that it
plays a pivotal role as an angiogenic modulator by stimulating vascular sprout formation and collagen fiber
restoration in ulcerated tissues. Conclusion: We conclude that curcumin remodels gastric tissues by restoring the
collagen architecture and accelerating angiogenesis.
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1480/1/ANTIOXIDANTS_%26__REDOX_SIGNALING_16(_4)351%2D362;2012[61].pdf
Sharma, Anamika Vivek and Ganguly, Krishnendu and Paul, Sumit and Maulik, Nilanjana and Swarnakar, Snehasikta (2012) Curcumin Heals Indomethacin-Induced Gastric Ulceration by Stimulation of Angiogenesis and Restitution of Collagen Fibers via VEGF and MMP-2 Mediated Signaling. Antioxidants & Redox Signaling, 16 (4). pp. 351-362.
 
Relation http://dx.doi.org/10.1089/ars.2011.4232
http://www.eprints.iicb.res.in/1480/