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Redox Regulation in Malaria: Current Concepts and Pharmacotherapeutic Implications

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Title Redox Regulation in Malaria: Current Concepts and Pharmacotherapeutic Implications
 
Creator Goyal, Manish
Alam, Athar
Bandyopadhyay, Uday
 
Subject Infectious Diseases and Immunology
 
Description Malaria imposes a serious threat to human and becomes more prevalent due to the emergence of drug resistant parasite.
Understanding of the underlying mechanism of drug resistance and identification of novel drug targets are key effective processes for the
management of malaria. Malaria parasite is highly susceptible to oxidative stress but lives in a pro-oxidant rich environment containing
oxygen and iron, which produce a large amount of reactive oxygen species. Management of oxidative stress in malaria parasite is tightly
regulated through active redox and antioxidant defense systems. The elevation of oxidative stress as a result of inhibition of any
component of this defense system leads to redox imbalance and ultimately parasite death. Therefore, redox system plays an indispensable
role for the survival of parasite within the host. Identification of key molecules, which disrupt parasite redox balance by altering key
redox reactions and promote oxidative stress in parasites, would be an effective approach to develop novel antimalarial drugs. During the
last few decades, contributions by researchers around the globe provide even better understanding of redox biology of malaria parasite.
Here, in this review, we are highlighting the knowledge gathered so far regarding the essential redox-active processes and their
components in malaria parasite to overcome elevated oxidative insults. We have also given maximum efforts to enlist currently used
redox-active antimalarials, their mode of action and pharmacotherapeutic implications.
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1505/1/CURRENT_MEDICINAL_CHEMISTRY___19(10)_1475%2D1503;2912[30].pdf
Goyal, Manish and Alam, Athar and Bandyopadhyay, Uday (2012) Redox Regulation in Malaria: Current Concepts and Pharmacotherapeutic Implications. Current Medicinal Chemistry, 19 (10). pp. 1475-1503.
 
Relation http://dx.doi.org/
http://www.eprints.iicb.res.in/1505/