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ETS-1 Protein Regulates Vascular Endothelial Growth Factor-induced Matrix Metalloproteinase-9 and Matrix Metalloproteinase-13 Expression in Human Ovarian Carcinoma Cell Line SKOV-3

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Title ETS-1 Protein Regulates Vascular Endothelial Growth
Factor-induced Matrix Metalloproteinase-9 and Matrix
Metalloproteinase-13 Expression in Human Ovarian
Carcinoma Cell Line SKOV-3
 
Creator Ghosh, Sonali
Basu, Moitri
Roy, Sib Sankar
 
Subject Cell Biology & Physiology
 
Description The mechanism of vascular endothelial growth factor (VEGF)-regulated expression of MMPs followed by
cancer cell scattering/invasion is poorly understood.
VEGF induces MMP-9, MMP-13, and ETS-1 through PI3K/AKT and p38 MAPK pathways in SKOV-3 cells.
VEGF induces ETS-1, which activates specific MMPS, leading to the invasion/scattering in SKOV-3 cells.
This study provides useful information that reveals the molecular mechanism of ovarian cancer metastasis.
 
Publisher American Society for Biochemistry and Molecular Biology
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1517/1/JOURNAL_OF_BIOLOGICAL_CHEMISTRY___287_(18(_15001%2D15015;2012[17].pdf
Ghosh, Sonali and Basu, Moitri and Roy, Sib Sankar (2012) ETS-1 Protein Regulates Vascular Endothelial Growth Factor-induced Matrix Metalloproteinase-9 and Matrix Metalloproteinase-13 Expression in Human Ovarian Carcinoma Cell Line SKOV-3. The Journal of Biological Chemistry, 287 (18). pp. 15001-15015.
 
Relation http://dx.doi.org/10.1074/jbc.M111.284034
http://www.eprints.iicb.res.in/1517/