Record Details

Mobilization of lymphoblasts from Bone Marrow to Peripheral Blood in Childhood Acute Lymphoblastic Leukaemia: Role of 9-O-Acetylated Sialoglycoproteins

EPrints@IICB

View Archive Info
 
 
Field Value
 
Title Mobilization of lymphoblasts from Bone Marrow to Peripheral Blood in Childhood Acute Lymphoblastic Leukaemia: Role of 9-O-Acetylated Sialoglycoproteins
 
Creator Chowdhury, Suchandra
Mandal, Chandan
Sarkara, Sayantani
Baga, Arup Kumar
Vlasak, Reinhard
Chandrac, Sarmila
Mandal, Chitra
 
Subject Infectious Diseases and Immunology
 
Description Childhood acute lymphoblastic leukaemia is characterized by aberrant proliferation and accumulation
of malignant lymphoblasts in bone marrow (BM), followed by their migration into circulation. An
enhanced cell-surface expression of ALL-associated 9-O-acetylated sialoglycoproteins (Neu5,9Ac2-GPs)
was demonstrated. Present investigation reports a positive correlation between the increased density of
Neu5,9Ac2-GPs on lymphoblasts and their mobilization from BM involving enhanced Neu5,9Ac2 on CD45
demonstrating modulation of FAK and ERK molecules. In contrast, a small population of cells, identified as
haematopoietic precursors, with comparatively lesser Neu5,9Ac2-GPs showed increased binding towards
BM stroma. Thus, Neu5,9Ac2-GPs is a developmentally regulated oncofoetal antigen, whose up-regulation
is imperative in the interaction between lymphoblasts and BM stroma, governing their mobilization into
circulation
 
Publisher Elsevier
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1522/1/LEUKEMIA_RESEARCH__36(_2)_146%2D155;2012[62].pdf
Chowdhury, Suchandra and Mandal, Chandan and Sarkara, Sayantani and Baga, Arup Kumar and Vlasak, Reinhard and Chandrac, Sarmila and Mandal, Chitra (2012) Mobilization of lymphoblasts from Bone Marrow to Peripheral Blood in Childhood Acute Lymphoblastic Leukaemia: Role of 9-O-Acetylated Sialoglycoproteins. Leukemia Research, 32 (2). pp. 146-154.
 
Relation http://dx.doi.org/10.1016/j.leukres.2011.10.017
http://www.eprints.iicb.res.in/1522/