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Modulation of Mitochondrial Respiratory Capacity by Carrier-Mediated Transfer of RNA in Vivo

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Title Modulation of Mitochondrial Respiratory Capacity by Carrier-Mediated Transfer of RNA in Vivo
 
Creator Jash, Sukanta
Chowdhury, Tapas
Adhya, Samit
 
Subject Molecular & Human Genetics
 
Description Genetic dysfunction of mitochondria is pathological, but an effective method of nucleic acid delivery to mitochondria
in vivo is lacking. Injection into rodents of tagged polycistronic RNAs (pcRNAs) encoding parts of
the organelle genome and bound to a carrier complex, resulted in rapid uptake and concentration of the
RNA in many tissues. The delivered RNA was localized to mitochondria. A pan-genomic cocktail of pcRNAs
restored mRNA levels, stimulated mitochondrial translation and respiratory capacity of skeletal muscle of
middle-aged and old rats. Thus, the carrier-based protocol may be suitable for delivery of functional RNAs
to mitochondria in vivo.
 
Publisher Elsevier
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1523/1/MITOCHONDRION___12_(_2)262%2D270;2012[44].pdf
Jash, Sukanta and Chowdhury, Tapas and Adhya, Samit (2012) Modulation of Mitochondrial Respiratory Capacity by Carrier-Mediated Transfer of RNA in Vivo. Mitochondrion, 12 (2). pp. 262-270.
 
Relation http://dx.doi.org/10.1016/j.mito.2011.10.001
http://www.eprints.iicb.res.in/1523/