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Identification and Characterization of DNA Methyl Transferases in Vibrio Cholerae

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Title Identification and Characterization of DNA Methyl Transferases in Vibrio Cholerae
 
Creator Banerjee, Sanjib
 
Subject Infectious Diseases and Immunology
 
Description Cholera (frequently called Asiatic cholera or epidemic cholera) is a severe diarrheal disease caused by the bacterium Vibrio cholerae. Transmission to humans is
by water or food. The natural reservoir of the organism is not known. It was long assumed to be humans, but some evidence suggests that it is the aquatic environment. V. cholerae produces cholera toxin, the model for enterotoxins, whose action on the mucosal epithelium is responsible for the characteristic diarrhea of the disease
cholera. In its extreme manifestation, cholera is one of the most rapidly fatal illnesses known. A healthy person may become hypotensive within an hour of the onset of
symptoms and may die within 2-3 hours if no treatment is provided. More commonly, the disease progresses from the first liquid stool to shock in 4-12 hours, with death
following in 18 hours to several days. The clinical description of cholera begins with sudden onset of massive
diarrhea. The patient may lose gallons of protein-free fluid and associated electrolytes, bicarbonates and ions within a day or two. This results from the activity of the cholera enterotoxin which activates the adenylate cyclase enzyme in the intestinal cells, converting them into pumps which extract water and electrolytes from blood and tissues
and pump it into the lumen of the intestine. This loss of fluid leads to dehydration, anuria, acidosis and shock. The watery diarrhea is speckled with flakes of mucus and
epithelial cells ("rice-water stool") and contains enormous numbers of vibrios. The loss of potassium ions may result in cardiac complications and circulatory failure. Untreated
cholera frequently results in high (50-60%) mortality rates.
 
Date 2007
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1524/1/SANJIB_PDF.pdf
Banerjee, Sanjib (2007) Identification and Characterization of DNA Methyl Transferases in Vibrio Cholerae. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1524/