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Role of Tau Kinases (CDK5R1 and GSK3B) in Parkinson’s Disease: A Study from India

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Title Role of Tau Kinases (CDK5R1 and GSK3B) in Parkinson’s Disease:
A Study from India
 
Creator Das, Gautami
Misra, Amar K
Das, Shyamal K
Ray, Kunal
Ray, Jharna
 
Subject Molecular & Human Genetics
 
Description Glycogen synthase kinase-3� (GSK3B) and cyclin-dependent kinase 5 (CDK5) are the 2 major protein kinases involved in abnormal
phosphorylation of tau. To determine their potential role in the pathogenesis of Parkinson’s disease (PD) we analyzed 2 functional single
nucleotide polymorphisms (SNPs) of GSK3B (rs334558 and rs6438552) and rs735555 of CDK5 regulatory subunit 1 (CDK5R1) in 373 PD
cases and 346 healthy controls of eastern India. The C,C and T,C haplotypes of GSK3B were respectively moderately associated with
increased risk and protection for late onset PD (LOPD) (odds ratio [OR], 1.399; 95% confidence interval [CI], 1.069 –1.829; p � 0.015, and
OR, 0.436; 95% CI, 0.222– 0.853; p � 0.016, respectively). Moreover, moderate to significant interaction between different loci were
observed for the entire PD cohort or late onset PD only. However, among these interactions, individuals carrying the (C/C) genotype at both
loci (rs6438552 and rs735555) had almost twice the risk of developing PD than those without this genotypic combination (OR, 1.871; 95%
CI, 1.181–2.964; p � 0.009). Thus, synergistic effect between the 2 major tau kinases, through these SNPs, appears to determine the risk
profile for PD.
 
Publisher Elsevier
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1529/1/NEUROBIOLOGY_OF_AGING__33_(7);2012[1].pdf
Das, Gautami and Misra, Amar K and Das, Shyamal K and Ray, Kunal and Ray, Jharna (2012) Role of Tau Kinases (CDK5R1 and GSK3B) in Parkinson’s Disease: A Study from India. Neurobiology of Aging, 33 (7). 1485.e9 -1485.e15.
 
Relation http://dx.doi.org/10.1016/j.neurobiolaging.2010.10.016
http://www.eprints.iicb.res.in/1529/