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Au(I)- and Pt(II)-N-heterocyclic carbene complexes with picoline functionalized benzimidazolin-2-ylidene ligands; synthesis, structures,electrochemistry and cytotoxicity studies

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Title Au(I)- and Pt(II)-N-heterocyclic carbene complexes with picoline functionalized benzimidazolin-2-ylidene ligands; synthesis, structures,electrochemistry and cytotoxicity studies
 
Creator Das Adhikary, Sirsendu
Bose, Dipayan
Mitra, Partha
Das Saha, Krishna
Bertolasid, Valerio
Dinda, Joydev
 
Subject Infectious Diseases and Immunology
 
Description Novel Au(I)-N-heterocyclic carbene complexes, 1-methyl-3-(2-pyridylmethyl)-
benzimidazolylidenegold(I)-chloride, 1; 1-benzyl-3-(2-pyridylmethyl)-
benzimidazolylidenegold(I)chloride, 2; and Pt(II)-N-heterocyclic carbene complexes 1-methyl-3-(2-
pyridylmethyl) benzimidazolylidene platinum(II)chloride, 3; and 1-benzyl-3-(2-pyridylmethyl)
benzimidazolylidene platinum-(II)chloride, 4, have been synthesized, based on CN-donor proligands
1-alkyl-3-(2-pyridylmeth-yl)-benzimidazoliumchloride L1 and L2 [alkyl, R = –CH3 = L1;
R = –CH2Ph = L2]. All the compounds have been synthesized and characterized by different
spectroscopic methods. The Au(I) complexes 1 and 2 have been synthesized by a silver carbene
transfer method. The solid-state structures of 1 and 3 have been determined by single crystal
X-ray diffraction studies. The square planar Pt(II) complexes 3 and 4 show a reversible
Pt(II)/Pt(IV) couple at 0.69 eV and 0.67 eV respectively. Among the complexes 1–4, complexes 1
and 3 have been used for cytotoxicity studies on the cell lines B16F10 (mouse melanoma), HepG2
(human hepatocarcinoma) and HeLa (human cervical carcinoma). IC50 values are compared with
cisplatin, among 1 and 3, the Au(I) complex 1 is more effective than Pt(II) complex 3.
 
Publisher Royal Society of Chemistry
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1530/1/NEW_JOURNAL_OF_CHEMISTRY___36_(3)759%2D767;2012[75].pdf
Das Adhikary, Sirsendu and Bose, Dipayan and Mitra, Partha and Das Saha, Krishna and Bertolasid, Valerio and Dinda, Joydev (2012) Au(I)- and Pt(II)-N-heterocyclic carbene complexes with picoline functionalized benzimidazolin-2-ylidene ligands; synthesis, structures,electrochemistry and cytotoxicity studies. New Journal of Chemistry, 36 (3). pp. 759-767.
 
Relation http://dx.doi.org/10.1039/c2nj20928d
http://www.eprints.iicb.res.in/1530/