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DBETH: A Database of Bacterial Exotoxins for Human

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Title DBETH: A Database of Bacterial Exotoxins for
Human
 
Creator Chakraborty, Abhijit
Ghosh, Sudeshna
Chowdhary, Garisha
Maulik, Ujjwal
Chakrabarti, Saikat
 
Subject Structural Biology & Bioinformatics
 
Description Pathogenic bacteria produce protein toxins to survive
in the hostile environments defined by the
host’s defense systems and immune response.
Recent progresses in high-throughput genome sequencing
and structure determination techniques
have contributed to a better understanding of mechanisms
of action of the bacterial toxins at the
cellular and molecular levels leading to pathogenicity.
It is fair to assume that with time more and
more unknown toxins will emerge not only by the
discovery of newer species but also due to the genetic
rearrangement of existing bacterial genomes.
Hence, it is crucial to organize a systematic compilation
and subsequent analyses of the inherent
features of known bacterial toxins. We developed
a Database for Bacterial ExoToxins (DBETH, http://
www.hpppi.iicb.res.in/btox/), which contains sequence,
structure, interaction network and analytical
results for 229 toxins categorized within 24
mechanistic and activity types from 26 bacterial
genuses. The main objective of this database
is to provide a comprehensive knowledgebase
for human pathogenic bacterial toxins where
various important sequence, structure and
physico-chemical property based analyses are
provided. Further, we have developed a prediction
server attached to this database which aims to
identify bacterial toxin like sequences either by establishing
homology with known toxin sequences/
domains or by classifying bacterial toxin specific
features using a support vector based machine
learning techniques.
 
Publisher Oxford University Press
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1531/1/NUCLEIC_ACIDS_RESEARCH___40__(D1)_D615%2DD620;2012[79].pdf
Chakraborty, Abhijit and Ghosh, Sudeshna and Chowdhary, Garisha and Maulik, Ujjwal and Chakrabarti, Saikat (2012) DBETH: A Database of Bacterial Exotoxins for Human. Nucleic Acids Research, 40. D615-D620.
 
Relation http://dx.doi.org/10.1093/nar/gkr942
http://www.eprints.iicb.res.in/1531/