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Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal Anti-inflammatory Drug-induced Gastropathy

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Title Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal
Anti-inflammatory Drug-induced Gastropathy
 
Creator Pal, Chinmay
Bindu, Samik
Dey, Sumanta
Alam, Athar
Goyal, Manish
Iqbal, Mohd. Shameel
Sarkar, Souvik
Kumar, Rahul
Halder, Kamal Krishna
Chatterjee Debnath, Mita
Adhikari, Susanta
Bandyopadhyay, Uday
 
Subject Infectious Diseases and Immunology
 
Description Non-steroidal anti-inflammatory drugs (NSAIDs) induce gastropathy by promoting mitochondrial pathology,
oxidative stress, and apoptosis in gastric mucosal cells.
We have synthesized SEGA (3a), a tryptamine-gallic acid hybrid, which prevents NSAID-induced gastropathy by
preventing mitochondrial oxidative stress, dysfunction, and apoptosis.
SEGA (3a) bears an immense therapeutic potential against NSAID-induced gastropathy.
This novel molecule is a significant addition in the discovery of gastroprotective drugs.
 
Publisher American Society for Biochemistry and Molecular Biology
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1533/1/OURNAL_OF_BIOLOGICAL_CHEMISTRY_287(_5)3495%2D3509;2912[63].pdf
Pal, Chinmay and Bindu, Samik and Dey, Sumanta and Alam, Athar and Goyal, Manish and Iqbal, Mohd. Shameel and Sarkar, Souvik and Kumar, Rahul and Halder, Kamal Krishna and Chatterjee Debnath, Mita and Adhikari, Susanta and Bandyopadhyay, Uday (2012) Tryptamine-Gallic Acid Hybrid Prevents Non-steroidal Anti-inflammatory Drug-induced Gastropathy. The Journal of Biological Chemistry, 287 (5). pp. 3495-3509.
 
Relation http://dx.doi.org/10.1074/jbc.M111.307199
http://www.eprints.iicb.res.in/1533/