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Studies on the Growth and Survival of Melanoma by Leishmanial Lipoprotein(s)

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Title Studies on the Growth and Survival of Melanoma by Leishmanial Lipoprotein(s)
 
Creator Majumder, Kajal Nayan
 
Subject Infectious Diseases and Immunology
 
Description The activity of any substance selectively inhibiting cellular growth, migration, adhesion and inducing cell death via apoptosis in immortal cancerous cells without
affecting the normal cell population determines its efficiency as a potential anti-cancer drug. In these respects bio-molecules having apoptosis inducing activities are now gaining much attention in biomedical research fields. Leishmania sp. (an eukaryotic protozoan parasite) has already been reported to have anti-proliferative as well as apoptotic effects on peripheral blood or bone marrow lymphocytes of visceral leishmaniasis patients (Barral et al., 1996). There is also an indication of apoptotic cell death with the reports of increased DNA damage, enhanced nitric oxide production and oxidative stress in patients with cutaneous leishmaniasis (Abdurrahim et al., 2005). Furthermore, Leishmania major is known to induce apoptotic cell death in epidermal keratinocytes during cutaneous leishmaniasis (Eidsmo et al., 2007). Also, in a previous investigation we have established that sphingolipid from an attenuated strain of Leishmania donovani promastigote (MHO/IN/1978/UR6) have apoptotic effects on melanoma cells (Ratha et al., 2006; 2007). So, there is an obvious interest to search of new components excepting the attenuated leishmanial sphingolipid to have a nature of apoptotic activity.
 
Date 2008
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1576/1/PDF_Kajal_Nayan_TH76.pdf
Majumder, Kajal Nayan (2008) Studies on the Growth and Survival of Melanoma by Leishmanial Lipoprotein(s). PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1576/