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Neural Transplantation in Experimental Model of Parkinson Disease

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Title Neural Transplantation in Experimental Model of Parkinson Disease
 
Creator Haobam, Reena
 
Subject Cell Biology & Physiology
 
Description Parkinson’s disease (PD) is a neurodegenerative disease characterized by loss of dopaminergic neurons in the substantia nigra pars compacta region of the brain. The
present therapy for the treatment of this disease is mainly symptomatic. The best treatment available is the combination of L-DOPA and carbidopa which can alleviate most
of the behavioral abnormalities observed in these patients. The search for the cure of this disease has instigated many minds to the development of modern strategies like deep brain stimulation, and cell replacement therapy (CRT). CRT aims at replenishing the lost neurons by transplanting new neurons. The last twenty five years have seen many developments in this field and has enhanced the understanding of the intricacies of CRT. It has faced much
hindrance in clinical trials with the development of side effects like dyskinesia and dystonia. The clinical trials had been rather inconsistent with some patients showing good results whereas many patients showing no improvements or exhibiting side effects. The current status calls for intensive research to develop and fabricate new methods for successful application of the technique in clinical set up.
The major focus of research in CRT at present is to develop new methods for the production of good and consistent source of transplantable cells which could be used for
transplantation. The use of animal models for pre-clinical trials in PD is a highly accepted means as many models are available that mimic the cardinal features of PD, that are
reproducible and quantifiable. The study is aimed at developing a new and easy method for differentiation of mouse embryonic stem cells into dopaminergic neurons that can be used for transplantation in rodent models of PD. Once this is achieved, the next target is to look
for one or more behavioral tests which could be used as the means for assessing the animals for the severity of the disease, and to investigate the quantum of cells to be
implanted for complete recovery of the disease in the parkinsonian animals. These studies have been completed and the results are combined to form this thesis.
 
Date 2008
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1582/1/REENA_HAOBAM_PDF_85.pdf
Haobam, Reena (2008) Neural Transplantation in Experimental Model of Parkinson Disease. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1582/