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Development and Physical Characterization of Chloramphenicol Loaded Biodegradable Nanoparticles for Prolonged Release

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Title Development and Physical Characterization of Chloramphenicol
Loaded Biodegradable Nanoparticles for Prolonged Release
 
Creator Mandal, B
Halder, Kamal Krishna
Dey, S K
Bhoumik, M
Chatterjee Debnath, Mita
Ghosh, Lakshmi Kanto
 
Subject Infectious Diseases and Immunology
 
Description The objectives of our study were to prepare a biodegradable nanoparticulate system of chloramphenicol (CHL) and to evaluate its ability to prolong in vitro release of CHL compared to free drug suspension (FDS). CHL-loaded polylactide-co-glycolide nanoparticles (CHL-PLGA-NPs) were prepared by an emulsion/solvent evaporation method using ethyl acetate and polyvinyl alcohol. CHL-PLGA-NPs were
characterized by particle size, zeta potential, infrared spectra, drug entrapment efficiency and in vitro
release kinetics measurement. Sonication was done with an ultrasound pulse sonicator at 70 W, 30 kHz for 60 s to produce stable NPs of mean size range from 277 nm to 433 nm. Drug to polymer ratio (D : P) was selected as formulation variable and significantly influenced entrapment efficiency (�30% to 66%) and release (p < 0.05). Entrapment of CHL in biodegradable NPs significantly prolonged drug release compared to FDS and thus implies potential antibiotic delivery system for ocular application.
 
Date 2009
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1588/1/N_C_Ghosh_1.pdf
Mandal, B and Halder, Kamal Krishna and Dey, S K and Bhoumik, M and Chatterjee Debnath, Mita and Ghosh, Lakshmi Kanto (2009) Development and Physical Characterization of Chloramphenicol Loaded Biodegradable Nanoparticles for Prolonged Release. Pharmazie, 64 (7). pp. 445-449.
 
Relation http://dx.doi.org/10.1691/ph.2009.8274
http://www.eprints.iicb.res.in/1588/