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Preparation, Characterization, and Biodistribution of Letrozole Loaded PLGA Nanoparticles in Ehrlich Ascites Tumor Bearing Mice

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Title Preparation, Characterization, and Biodistribution of Letrozole Loaded PLGA Nanoparticles in Ehrlich Ascites Tumor Bearing Mice
 
Creator Mondal, Nita
Halder, Kamal Krishna
Kamila, Madan Mohan
Chatterjee Debnath, Mita
Pal, Tapan K
Ghosal , Saroj K
Sarkar, Bharat R
Ganguly, Shantanu
 
Subject Infectious Diseases and Immunology
 
Description Letrozole (LTZ) incorporated PLGA nanoparticles were prepared by solvent displacement technique and
characterized by transmission electron microscopy, poly-dispersity index and zeta potential measurement.
Radiolabeling of free LTZ and LTZ-loaded PLGA NPs was performed with technetium-99m with high labeling efficiency. The labeled complex showed good in vitro stability as verified by DTPA challenge test. The labeled complexes also showed significant in vivo stability when incubated in rat serum for 24 h. Biodistribution studies of 99mTc-labeled complexes were performed after intravenous administration in
normal mice and Ehrlich Ascites tumor bearing mice. Compared to free LTZ, LTZ-loaded PLGA NPs exhibited
significantly lower uptake by the organs of RES. The tumor concentration of LTZ-loaded PLGA NPs was 4.65 times higher than that of free LTZ at 4 h post-injection. This study indicates the capability of PLGA nanopartcles in enhancing the tumor uptake of letrozole.
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1589/1/N_C_Ghosh_3.pdf
Mondal, Nita and Halder, Kamal Krishna and Kamila, Madan Mohan and Chatterjee Debnath, Mita and Pal, Tapan K and Ghosal , Saroj K and Sarkar, Bharat R and Ganguly, Shantanu (2010) Preparation, Characterization, and Biodistribution of Letrozole Loaded PLGA Nanoparticles in Ehrlich Ascites Tumor Bearing Mice. International Journal of Pharmaceutics , 397 (1-2). pp. 194-200.
 
Relation http://dx.doi.org/10.1016/j.ijpharm.2010.06.049
http://www.eprints.iicb.res.in/1589/