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Gene Induction During Host-Pathogen Interaction

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Title Gene Induction During Host-Pathogen Interaction
 
Creator Bhagat, Abha
 
Subject Infectious Diseases and Immunology
 
Description The disease cholera, one of the most ancient of human afflictions, has been described in ancient texts more than 2,500 years old. Cholera (frequently called Asiatic
cholera or epidemic cholera) is a severe diarrheal disease caused by the bacterium Vibrio cholerae. Transmission to humans is by water or food. The natural reservoir of the
organism is not known. It was long assumed to be humans, but some evidence suggests that it is the aquatic environment.“It is characteristic of cholera, not only of the disease in its developed and alarming form, but equally of the slightest diarrhea, that all matters which the patients discharge from their stomachs and bowels are infective. Even a single case of cholera, perhaps of the slightest degree, and perhaps quite unsuspected in the neighborhood, may, if local conditions cooperate exert a terribly infective power on considerable masses of the population” (Mosley and Khan 1979) The idea that the clinical manifestation of cholera is due to a toxin really has its root in the writing of John Snow, who provided convincing epidemiological evidence for the role of piped Thames River water in the transmission of cholera during the London epidemic (Snow,1885). Nearly thirty years later, Robert Koch reported of the cholera bacillus from pond water during a cholera outbreak, leading bacteriologic plausibility to water-borne cholera transmission (Koch, 1884), and identified Vibrio cholerae as the causative agent of cholera. Cholera is one of the most ancient human afflictions that have been described in Arabian, Hindu, Greek and Roman texts over 2,500 years ago. Illness
and death due to dehydrating diarrhea and vomiting can be recognized in the writing of Susruta, Galen and Wang-Shooho. Accounts of cholera-like diseases go back to the times of Hippocrates and Lord Buddha (Barua, 1992). Hippocrates was the first to use the term cholera (χОλέρη), which probably originates from Greek word χόλάζ (gut) or from the word χολέδρή, meaning gutter (Barua, 1992; Pollitzer, 1909). Both words give a very suitable description of the main symptoms of the disease cholera, severe diarrhea and vomiting.
 
Date 2008
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1593/1/Abha_PDF_TH3.pdf
Bhagat, Abha (2008) Gene Induction During Host-Pathogen Interaction. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1593/