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Conformation and Cytotoxicity of a Tetrapeptide Constellated with Alternative D- and L-proline

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Title Conformation and Cytotoxicity of a Tetrapeptide Constellated with
Alternative D- and L-proline
 
Creator Banerji, Biswadip
Pramanik, Sumit Kumar
Pal, Uttam
Maiti, Nakul Chandra
 
Subject Chemistry
Structural Biology & Bioinformatics
 
Description Proline containing peptides are highly important due to their
natural abundance in various secondary structural elements like
turns (b turn and c turn etc.) in proteins. Here the conformation,
cytotoxicity and structure of a unique tetrapeptide composed of
alternative D- and L-proline residues are discussed. The peptide
showed a polyproline II like conformation in dilute aqueous
solution. The aqueous solution of the peptide self-assembled to
form spheroidal oligomers with a diameter of y90 nm. The
morphological features were confirmed by bright field confocal
images, TEM analysis and AFM. The alternative D- and Lproline
residues in the peptide showed toxicity towards cancer cell
lines and y50% cell death was recorded against three different
types of cancer cells (Neura 2a, HEK 293 and Hep G2).
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1614/1/RSC_ADVANCES___2_(_17)_6744%2D6747;2012[101].pdf
Banerji, Biswadip and Pramanik, Sumit Kumar and Pal, Uttam and Maiti, Nakul Chandra (2012) Conformation and Cytotoxicity of a Tetrapeptide Constellated with Alternative D- and L-proline. RSC Advances, 2 (1). pp. 6744-6747.
 
Relation http://dx.doi.org/10.1039/c2ra20616a
http://www.eprints.iicb.res.in/1614/