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Innate Immune Defense in Visceral Leishmaniasis: Cytokine Mediated Protective role by Allogeneic Effector Cell

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Title Innate Immune Defense in Visceral Leishmaniasis: Cytokine Mediated Protective
role by Allogeneic Effector Cell
 
Creator Manna, Partha Pratim
Chakrabarti, Ganes
Bandyopadhyay, Santu
 
Subject Infectious Diseases and Immunology
 
Description Antileishmanial role of mouse splenic natural killer (NK) cell was studied in allogeneic condition. In vitro
data indicates that NK cells of allogeneic (C57BL/6, H2b) non-leishmania exposed mouse have strong
antileishmanial effect against Leishmania donovani infected BALB/c (H2d) macrophages. Physical contact
between the effector (NK cell) and the target cells (infected macrophages) is essential in this system
since; cell free supernatant generated after coculturing of effector cells with infected target cells fails to
elicit any antileishmanial effect. Although NK cells from allogeneic mouse are strongly attached to the
infected macrophages but unable to kill it in such interaction. The antileishmanial effect of allogeneic
NK cells is mediated by TNF-� and not by IFN-�. In vivo cellular therapy of established infection with NK
cells from non-leishmania exposed allogeneic mouse significantly reduces the total parasite burden in
the spleen of infected animal
 
Publisher Elsevier
 
Date 2010
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1615/1/Vaccine%2C_2010.pdf
Manna, Partha Pratim and Chakrabarti, Ganes and Bandyopadhyay, Santu (2010) Innate Immune Defense in Visceral Leishmaniasis: Cytokine Mediated Protective role by Allogeneic Effector Cell. Vaccine, 28. pp. 803-810.
 
Relation http://dx.doi.org/10.1016/j.vaccine.2009.10.053
http://www.eprints.iicb.res.in/1615/