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Interaction of Leishmania Parasites with Dendritic Cells and its Functional Consequences

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Title Interaction of Leishmania Parasites with Dendritic Cells and its Functional
Consequences
 
Creator Ghosh, Monidipa
Bandyopadhyay, Santu
 
Subject Infectious Diseases and Immunology
 
Description Interaction between dendritic cells (DC) and T cells is essential for the generation of cell mediated immunity and
thus DC play a critical role in the initiation of immune responses against Leishmania parasites. Although macrophages
(Mf) are the major targets of all species of Leishmania, a number of studies demonstrated the infection of DC by
Leishmania. DC specific intracellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN), has been reported to be
the receptor for Leishmania amastigotes. The functional consequences in DC after Leishmania infections appear to
depend on species of Leishmania. Some species of Leishmania enhance the surface expression of co-stimulatory
molecules and CD40-ligand-induced IL-12 production in DC. On the other hand other species down-regulate costimulatory
molecules and inhibit IL-12 production. The intrinsic differences among Leishmania species with regard to
alteration of cell surface molecules and IL-12 production in DC may contribute to the healing and non-healing forms
of the disease
 
Publisher Elsevier
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1623/1/Immunobiology%2C_2004.pdf
Ghosh, Monidipa and Bandyopadhyay, Santu (2004) Interaction of Leishmania Parasites with Dendritic Cells and its Functional Consequences. Immunobiology, 209. pp. 173-177.
 
Relation http://dx.doi.org/10.1016/j.imbio.2004.02.007
http://www.eprints.iicb.res.in/1623/