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leishmania donovani DNA Topoisomerases i & ii : Molecular Biological Studies in Relation to Their Mode of Action

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Title leishmania donovani DNA Topoisomerases i & ii :
Molecular Biological Studies in Relation to Their Mode of Action
 
Creator Das, Rakhee
 
Subject Infectious Diseases and Immunology
 
Description The term “leishmaniasis” covers a range of disease presentations, most commonly seen in the tropical areas of the New World and around the Mediterranean sea. Leishmaniasis is not a single entity but comprises of a variety of syndromes, primarily due to a variety of parasites affecting different populations and each related to a characteristic vector and animal reservoirs. It is
caused by species of intracellular parasite belonging to the genus ‘Leishmania’. The problem is not only complex but also cosmopolitan. Until about 60 years ago leishmaniasis was thought to be important only in India, China, The Middle east, Southern Europe and parts of southern
America. But now it is recognized in all continents except in Australia and Antarctica. The synonym “Kala azar” comes from Hindi, and means black poison or black fever, because of the darkening of skin pigmentation on the forehead and hands; other local names are given to different
patterns of the disease Leishmaniasis has been called a
“dynamic disease” gradually spreading, with new foci of infection arising in scattered areas of the globe. The WHO
has estimated that there are 12 million people infected and 350 million at risk (1992) (Fig 1.1). Epidemiological data
shows that leishmaniasis at present is the most fatal disease second only to malaria (WHO, 2000). Leishmaniasis
infected areas also broadly overlap with areas in which human immunodeficiency virus (HIV) infections are increasing and about a third of the patients die during their first visceral leishmaniasis episode. Over the last 10 years, endemic regions have been spreading further afield and there has been a sharp increase in the number of recorded cases of the disease. Developing countries like Afghanistan, Bangladesh, Bolivia, Brazil, India, Iran, Peru,
Saudi Arabia and Syria are worst affected. Unfortunately, as notification is obligatory in only 33 of the 88 countries affected, a substantial number of cases are never recorded. In fact, only 6,00,000 cases of the 2 million actual occurrences are officially recorded per year. In addition, deadly epidemics periodically flare up, as did in Sudan in early nineties (Mortality rate in an excess of 1,00,000) and in Kabul in late nineties (Estimated 2,00,000 cases). Moreover the lack of correlation between Leishmania taxa and the clinical disease produced makes the actual
detection and treatment more difficult. Fig. 1.1. Areas showing world wide distribution of Leishmaniasis
 
Date 2008
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1658/1/Rakhee_Das_Thesis_pdf.pdf
Das, Rakhee (2008) leishmania donovani DNA Topoisomerases i & ii : Molecular Biological Studies in Relation to Their Mode of Action. PhD thesis, Jadavpur University.
 
Relation http://www.eprints.iicb.res.in/1658/