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Chloramphenicol-Incorporated Poly Lactide-co-Glycolide (PLGA) Nanoparticles: Formulation, Characterization, Technetium-99m Labeling and Biodistribution Studies

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Title Chloramphenicol-Incorporated Poly Lactide-co-Glycolide (PLGA)
Nanoparticles: Formulation, Characterization, Technetium-99m Labeling
and Biodistribution Studies
 
Creator Halder, Kamal Krishna
Mondal, Bivash
Chatterjee Debnath, Mita
Bera, Hriday
Ghosh, Lakshmi Kanto
Gupta, Bijon Kumar
 
Subject Infectious Diseases and Immunology
 
Description Chloramphenicol-loaded (CHL) poly-D,L-lactic-co-glycolic acid (PLGA) nanoparticles (NPs) were prepared by
emulsification solvent evaporation technique either by using polyvinyl alcohol (PVA) as emulsion stabilizer or polysorbate-
80 (PS-80) as surfactant and characterised by transmission electron microscopy, zeta-potential measurements. The NPs were
radiolabeled with technetium-99m (99mTc) by stannous reduction method. Labeling conditions were optimised to achieve
high-labeling efficiency, in vitro and in vivo (serum) stability. The labeled complexes also showed very low transchelation as
determined by DTPA challenge test. Biodistribution studies of 99mTc-labeled complexes were performed after intravenous
administration in mice. The CHL-loaded PLGA NPs coated with PS-80 exhibited relatively high brain uptake with
comparatively low accumulation in bone marrow to that of free drug and CHL-loaded PLGA NPs (PVA, used as emulsion
stabilizer) at 24 h post injection time period. This indicates the usefulness of the above delivery system for prolonged use of the
antibiotic.
 
Publisher Taylor & Francis
 
Date 2008
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://www.eprints.iicb.res.in/1662/1/(1)._Kamal%2DCHL.pdf
Halder, Kamal Krishna and Mondal, Bivash and Chatterjee Debnath, Mita and Bera, Hriday and Ghosh, Lakshmi Kanto and Gupta, Bijon Kumar (2008) Chloramphenicol-Incorporated Poly Lactide-co-Glycolide (PLGA) Nanoparticles: Formulation, Characterization, Technetium-99m Labeling and Biodistribution Studies. Journal of Drug Targeting, 16 (4). pp. 311-320. ISSN 1061-186X
 
Relation http://dx.doi.org/10.1080/10611860801899300
http://www.eprints.iicb.res.in/1662/